Basic Information
VIS ID
TVIS10008340
Fusion event
HBV-LOC105373760 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
608
Orient
+
Integrated sequence
CGGGACCATGCCGGACCTGCATGACTACTGCTCAAGGAACCTCTATGTATCCCTCCTGTTGCTGTACCAAACCTTCGGACGGAAATTGCACCTGTATTCC| |CATCCCATCATCCTGGGCTTTCGGAAAATTCCTATGGGAGTGGGCCTCAGCCCGTTTCTCCTGGCTCAGTTTACTAGTGCCATTTGTTCAGTGGTTCGTA
Host Sequence
Chromosome
chr2
Cytoband
q31.1
Reference genome
GRCh37/hg19
Start
177957993/177093265 (Hg38)
End
177957993/177093265 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA2G
Target gene
LOC105373760
Nearest miRNA
hsa-mir-10b/Upstream/492213; hsa-mir-1244-1/Downstream/119461;
Nearest TSS
ENST00000437798/Upstream/36949; ENST00000432457/Downstream/71251;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/454900, chr2-CpG: 98/Downstream/119192
Nearby gene
LINC01116(-455691) ; HNRNPA3(+119429) ;
Upstream sequence
CAGTCTAAGGTTCCTGCCAGAAAGTCTCGAAATGACCACTATGGATGTCCGTGTGAATCCTGCTCATTGCACCTCCACCGACATGAAGCTCACACCATCT
Downstream sequence
CTTAGTTTTCCCACTAGCATGGATGGGATGCTCATTCTTCATGCTCCAATGCTGTCTTGCCTCATTTATAATGACTTTATGTTAGTCAAAATAAATGTTT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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