Basic Information
VIS ID
TVIS10008341
Fusion event
HBV-LINC01934 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|Polymerase|
Start
2390
Orient
-
Integrated sequence
CAGCTTATAGACCACCAAATGCCCCTATCCTATCAACACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCC| |TCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATTCCTTGGACTCATAAGGTGGGGAACTTTACTGG
Host Sequence
Chromosome
chr2
Cytoband
q31.3
Reference genome
GRCh37/hg19
Start
182140588/181275861 (Hg38)
End
182140588/181275861 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA2G
Target gene
LINC01934
Nearest miRNA
hsa-mir-10b/Upstream/1414953; hsa-mir-1244-1/Downstream/29732;
Nearest TSS
ENST00000437798/Upstream/72505; ENST00000476089/Downstream/149888;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/294662, chr2-CpG: 119/Downstream/181173
Nearby gene
UBE2E3(-212438) ; MIR4437(+29732) ;
Upstream sequence
GTGCAAGAGACACAGTGCATAAGATGTGCActaaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaacccGgg
Downstream sequence
ttaatgtgaggtgcaagagacacagtgcataagatgtggtaggtggaagtgaagtagaaagcatattcttttatgctgggaaggtcacttgagggcactg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate