Basic Information
VIS ID
TVIS10008347
Fusion event
HBV-chr2 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|
Start
3157
Orient
+
Integrated sequence
CTCAGGGCATACTACAAACTTTGCCAGCAAATCCGCCTCCTGCCTCCACCAATCGCCAGTCAGGAAGGCAGCCTACCCCGCTGTCTCCACCTTTGAGAAA| |CACTCATCCTCAGGCCATGCAGTGG
Host Sequence
Chromosome
chr2
Cytoband
p22.3
Reference genome
GRCh37/hg19
Start
32040266/31815197 (Hg38)
End
32040266/31815197 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-1301/Upstream/3818748; hsa-mir-10b/Downstream/716956;
Nearest TSS
ENST00000437798/Upstream/11217; ENST00000605811/Downstream/38226;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/233484, chr2-CpG: 174/Downstream/194387
Nearby gene
SRD5A2(-234226) ; MEMO1(+52628) ;
Upstream sequence
CTAGTTGTATTCTAGTTTTACTAACTGCCAAAGGTTTTTTGCAATAATCTCAGTCACCCACTGGAGATGTTCTTAAGCCCTGAGAAGACAGATCATCATT
Downstream sequence
CACAGAAATAGACAGCACTGAGCAAAAACACATTGCTGTCCATCCATCTTCATCTTTTAGTAATCAACAAGTGCTTTCAAAATACTATGAGTTAGATAGA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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