Basic Information
VIS ID
TVIS10008350
Fusion event
HBV-chr2 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1793
Orient
-
Integrated sequence
GACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATA| |AATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGG
Host Sequence
Chromosome
chr2
Cytoband
q11.2
Reference genome
GRCh37/hg19
Start
99818050/99201587 (Hg38)
End
99818050/99201587 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA2S ; FRA2A
Nearest miRNA
hsa-mir-1285-2/Upstream/2403234; hsa-mir-10b/Downstream/2107863;
Nearest TSS
ENST00000437798/Upstream/15411; ENST00000465095/Downstream/52694;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/20427, chr2-CpG: 148/Downstream/134438
Nearby gene
MRPL30(-2030) ; LYG2(+40661) ;
Upstream sequence
GAGAAGGGATTAGCTCTAGCCCAACTACAGACCATGCTTCCGGGACATCCTCCTGGTCTTGACAGTGGTGAAAATCTGGATGTCATGAATTCTGTGGCCT
Downstream sequence
GACTTCACCTGCCCTTGACTAAAGAGGGGGATtgaggaaaagaaaaagcaacttctgacagccaggaactggcctggaactctcaggccttggtgtttcc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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