Basic Information
VIS ID
TVIS10008353
Fusion event
HBV-chr21 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
563
Orient
-
Integrated sequence
TGTTGCCCGTTTGTCCTCTAATTCCAGGATCCTCAACAACCAGCACGGGACCATGCCGGACCTGCATGACTACTGCTCAAGGAACCTCTATGTATCCCTC| |CTGTTGCTGTACCAAACCTTCGGACGGAAATTGCACCTGTATTCCCATCCCATCATCCTGGGCTTTCGGAAAATTCCTATGGGAGTGGGCCTCAGCCCGT
Host Sequence
Chromosome
chr21
Cytoband
q22.2
Reference genome
GRCh37/hg19
Start
40323718/38951793 (Hg38)
End
40323718/38951793 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-let-7c/Upstream/3230985; hsa-mir-3197/Downstream/495217;
Nearest TSS
ENST00000624081/Upstream/13364; ENST00000608767/Downstream/4674;
Nearest CpG islands
None/Target, chr21-CpG: 261/Upstream/128868, chr21-CpG: 115/Downstream/231045
Nearby gene
ETS2(-126840) ; PSMG1(+223654) ;
Nearest cancer related gene
ETS2(OG, -126840) ;
Upstream sequence
GAGCCAGGGGTGCTTGCCATTTTCATCTGCCAAATGAGGTTATAGAAGACTCTGTTTTAGAAGGGCCACAGCCCAGAGGTCTAGGTGATGCTGAAAAATG
Downstream sequence
ACACATGGCCGATTCCCAAAGAAATGATAGAATTTCCCATCTAGCAAAGATACCAGAAAGCTGAACTCACCTTTCATCATTTTTAAAAAAGGATAACGTC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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