Basic Information
VIS ID
TVIS10008356
Fusion event
HBV-chr3 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
524
Orient
+
Integrated sequence
GCCTCATCTTCTTGTTGGTTCTTCTGGACTATCAAGGTATGTTGCCCGTTTGTCCTCTAATTCCAGGATCCTCAACAACCAGCACGGGACCATGCCGGAC| |CTGCATGACTACTGCTCAAGGAACCTCTATGTATCCCTCCTGTTGCTGTACCAAACCTTCGGACGGAAATTGCACCTGTATTCCCATCCCATCATCCTGG
Host Sequence
Chromosome
chr3
Cytoband
q26.31
Reference genome
GRCh37/hg19
Start
174080430/174362640 (Hg38)
End
174080430/174362640 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-let-7g/Upstream/3255881; hsa-mir-1224/Downstream/1006900;
Nearest TSS
ENST00000440867/Upstream/87326; ENST00000478624/Downstream/75933;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/964655, chr3-CpG: 28/Downstream/14565
Nearby gene
NLGN1(-79314) ; NAALADL2(+496681) ;
Upstream sequence
cagccttggactcctggacacagtgatccttccacctcctgagtagctgggactataggcacacaccactatgcccagttacttttgttttgtagagaca
Downstream sequence
cacccagacatactgaatagaggcctgcattgtttaaagccagattgccaggtaattcacatgcatgttaCTAGTTGAGTGTTACTGTCGTCAGAACACA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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