VISDB Viral Integration Site DataBase

VIS ID

TVIS10008358

Fusion event

HBV-ARHGEF3 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

S protein|Polymerase|large S protein|middle S protein|

Start

192

Orient

+

Integrated sequence

TGTTCTGACTACTGCCTCTCCCTTATCGTCAATCTTCTCGAGGATTGGGGACCCTGCGCTGAACATGGAGAACATCACATCAGGATTCCTAGGACCCCTT| |CTCGTGTTACAGGCGGGGTTTTTCTTGTTGACAAGAATCCTCACAATACCGCAGAGTCTAGACTCGTGGTGGACTTCTCTCAATTTTCTAGGGGGAACTA

Chromosome

chr3

Cytoband

p14.3

Reference genome

Start

End

56939291/56905263 (Hg38)

Orient

-

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-138-5p ; hsa-mir-373-3p ; hsa-mir-335-5p ; hsa-mir-769-5p ; hsa-mir-377-5p ; hsa-mir-485-5p ; hsa-mir-3680-3p ; hsa-mir-557 ; hsa-mir-507 ; hsa-mir-450b-5p ; hsa-mir-889-3p ; hsa-mir-4793-5p ; hsa-mir-5196-3p

Nearest miRNA

hsa-let-7g/Upstream/1052669; hsa-mir-12124/Downstream/3712542;

Nearest TSS

Nearest CpG islands

None/Target, chr3-CpG: 148/Upstream/103081, chr3-CpG: 112/Downstream/173458

Upstream sequence

TAACCATTATGGTTAACACCTGTGTTGTAATTGTTTGTTGACTTTTTCCCTCACTTGATTGATTGattcattcattcaacaaatatttattcaccaccca

Downstream sequence

CATCCCAGCCATCGCTTCCTTCTGCATTCTTCCAGACCAGCCCTAGACATAAATAAGCAAATCAtctattttacccaatgctaacacactataggtactg