hsa-mir-6844 _LIHC.png
ROBO2 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10008360
Fusion event
HBV-ROBO2 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
1207
Orient
+
Integrated sequence
CTTACAAGGCCTTTCTGTGTAAACAATACCTGAACCTTTACCCCGTTGCCCGGCAACGGCCAGGTCTGTGCCAAGTGTTTGCTGACGCAACCCCCACTGG| |CTGGGGCTTGGTCATGGGCCATCAGCGCATGCGTGGAACCTTTTCGGCTCCTCTGCCGATCCATACTGCGGAACTCCTAGCCGCTTGTTTTGCTCGCAGC
Host Sequence
Chromosome
chr3
Cytoband
p12.3
Reference genome
GRCh37/hg19
Start
76645486/76596335 (Hg38)
End
76645486/76596335 (Hg38)
Orient
+
Location type
Intronic
Target gene
ROBO2
miRNAs that regulate target gene
hsa-mir-145-5p ; hsa-mir-342-5p ; hsa-mir-514b-3p ; hsa-mir-514a-3p ; hsa-mir-6844 ; hsa-mir-4801 ; hsa-mir-4731-3p ; hsa-mir-8084
Nearest miRNA
hsa-let-7g/Upstream/857972; hsa-mir-12124/Downstream/2911552;
Nearest TSS
ENST00000440867/Upstream/285239; ENST00000471893/Downstream/443551;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/689178, chr3-CpG: 63/Downstream/443012
Nearby gene
ZNF717(-811231) ; ROBO2(+443808) ;
Upstream sequence
TATGGTTGTGTGGATGGGCTCTATTTTCTGTCCCCAGCTAGTTACCTGTTCATGCACTACACCCCTTGGATCCTCTGTTAAAGAGAGACTTAGTAATTGG
Downstream sequence
ATAAGTGATAGGAGAGAGAATATGTTAAATAACATAGACTATGAAGAGTAGCGCATGTAGAAATTAGGAAAGACACTTGAGAATCCAGTGGGATGTGTTT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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