Basic Information
VIS ID
TVIS10008361
Fusion event
HBV-chr3 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|middle S protein|
Start
86
Orient
-
Integrated sequence
AATTCCACAACCTTCCACCAAACTCTGCAAGATCCCAGAGTGAGAGGCCTGTATTTCCCTGCTGGTGGCTCCAGTTCAGGAACAGT| |AAACCCTGTTCTGACTACTGCCTCTCCCTTATCGTCAATCTTCTCGAGGATTGGGGACCCTGCGCTGAACATGGAGAACATCACATCAGGATTCCTAGGA
Host Sequence
Chromosome
chr3
Cytoband
p12.2
Reference genome
GRCh37/hg19
Start
81256118/81206967 (Hg38)
End
81256118/81206967 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-let-7g/Upstream/1698998; hsa-mir-12124/Downstream/4178743;
Nearest TSS
ENST00000440867/Upstream/213099; ENST00000471614/Downstream/1947;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/1440217, chr3-CpG: 75/Downstream/554197
Nearby gene
ROBO1(-1439059) ; GBE1(+282732) ;
Nearest cancer related gene
ROBO1(TSG, -1439059) ;
Upstream sequence
TTCCAGATTTCAACAAATTCAATTTACATTTCAATTTGATATGCACACCCAATCCCTGAATCCACTATCCCATTGGCCCATTTTGTGATTCCTAATGGGC
Downstream sequence
tatgcttttatgtaatttgcacaaaggcatcatacaagccataagcagccctgTCTGCTGACTCTATGAAGACAGACATTTTAaatgtctaaattagttc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate