Basic Information
VIS ID
TVIS10008371
Fusion event
HBV-chr4 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|Polymerase|
Start
2390
Orient
-
Integrated sequence
CAGCTTATAGACCACCAAATGCCCCTATCCTATCAACACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCC| |TCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATTCCTTGGACTCATAAGGTGGGGAACTTTACTGG
Host Sequence
Chromosome
chr4
Cytoband
q35.2
Reference genome
GRCh37/hg19
Start
191044191/190123036 (Hg38)
End
191044191/190123036 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-12113/Upstream/5184596;
Nearest TSS
ENST00000502981/Upstream/58534; ENST00000616166/Downstream/50738;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/30582, chr4-CpG: 24/Downstream/50097
Nearby gene
DUX4L2(-30715) ;
Upstream sequence
CAGACACATTTTAAAATGTTGATAGTTATATTCCAATGTGAATTTGAAAACTACTGTAGAAgccaggcacagtggtgtgtgccagtagtcccagctacac
Downstream sequence
ggttagggttagggttagggttagggttagggttagggttcgggttcgggttcgggttcgggttcgggttcgggttcgggttcggNNNNNNNNNNNNNNN
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate