Basic Information
VIS ID
TVIS10008372
Fusion event
HBV-MIR548AJ2 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2026
Orient
+
Integrated sequence
TTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCT| |TAGAGTCTCCTGAGCATTGTTCACCTCACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCTAGCTACCTGGGTGGGTGTTAA
Host Sequence
Chromosome
chr4
Cytoband
p15.2
Reference genome
GRCh37/hg19
Start
23211361/23209738 (Hg38)
End
23211361/23209738 (Hg38)
Orient
+
Location type
ncRNA_intronic
Fragile sites / regions
FRA4D
Target gene
MIR548AJ2
Nearest miRNA
hsa-mir-12113/Upstream/694353; hsa-mir-1243/Downstream/1310454;
Nearest TSS
ENST00000502981/Upstream/104236; ENST00000499715/Downstream/75835;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/693313, chr4-CpG: 266/Downstream/1260339
Upstream sequence
gagttacactgttgtcatgcaggccggagtgcaatggcacaatctcgactcactgcaacctctgcttcccaggttcaagcaattctcctgcctcagcctc
Downstream sequence
TTCAACCCTTGTTGAAACAGCAATGAATCTAACTTCAGTGGGAGTCACTGCAGCACTGCAATTTTACCAATAGCTCAGGATAcaatcaaacctcattaac
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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