Basic Information
VIS ID
TVIS10008384
Fusion event
HBV-chr5 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
precore/core protein|Core and e antigen|Polymerase|
Start
2390
Orient
-
Integrated sequence
CAGCTTATAGACCACCAAATGCCCCTATCCTATCAACACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCC| |TCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATTCCTTGGACTCATAAGGTGGGGAACTTTACTGG
Host Sequence
Chromosome
chr5
Cytoband
p15.33
Reference genome
End
10967/10967 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-10397/Downstream/1051929;
Nearest CpG islands
None/Target, None/Upstream, chr5-CpG: 87/Downstream/39723
Nearby gene
PLEKHG4B(+129406) ;
Upstream sequence
taatcccagctacttgggaggctgagggaggagaattgcttgaacctgggaggcagaggttgcagtgagcggagattgagccactgcaatccagcctggg
Downstream sequence
aaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaacc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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