Basic Information
VIS ID
TVIS10008394
Fusion event
HBV-chr5 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|Polymerase|
Start
2353
Orient
-
Integrated sequence
TATTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCTCCAGCTTATAGACCACCAAATGCCCCTATCCTATCAACACTTCCGGAGACTACTGTTGTTAGAC| |GACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTA
Host Sequence
Chromosome
chr5
Cytoband
q31.3
Reference genome
GRCh37/hg19
Start
143981058/144601495 (Hg38)
End
143981058/144601495 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-10397/Upstream/921524; hsa-mir-103a-1/Downstream/4460818;
Nearest TSS
ENST00000502646/Upstream/396218; ENST00000512571/Downstream/627487;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/2574, chr5-CpG: 43/Downstream/1233591
Nearby gene
KCTD16(-124114) ; PRELID2(+1157524) ;
Upstream sequence
ccctcctcacacccagtccggcttgcagtttcgttctgtgattagccctcccccatctgcccagcaatttccgcttaaaaaggtggctagaggtaaaggc
Downstream sequence
TGAAAAATGACACGTTATCTACATACCTTACTACTGGCATCTCTCACTCTGTCTATTCCATGTTGTTCAAAGGCAGGATGGGCAATTCTCAAAGCCATCC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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