Basic Information
VIS ID
TVIS10008395
Fusion event
HBV-LOC107986490 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2048
Orient
-
Integrated sequence
TCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTC| |ACCTCACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCTAGCTACCTGGGTGGGTGTTAATTTGGAAGATCCAGCGTCTAGA
Host Sequence
Chromosome
chr5
Cytoband
q35.3
Reference genome
GRCh37/hg19
Start
177279704/177852703 (Hg38)
End
177279704/177852703 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA5G
Target gene
LOC107986490
Nearest miRNA
hsa-mir-10397/Upstream/1223203; hsa-mir-1229/Downstream/1945575;
Nearest TSS
ENST00000502646/Upstream/49359; ENST00000502514/Downstream/18480;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/69181, chr5-CpG: 58/Downstream/22719
Nearby gene
FAM153A(-72199) ; LOC728554(+22558) ;
Upstream sequence
TACAGAGTTGAGCTCaatgcaagaagttcccaaaaatgatgagttcctcatttctgaacacatttaagcagagcctggaagattacttgAGAGCAAGAAG
Downstream sequence
agctacctgggaggctgaaccacaagaatcacttgaacccgggaggtggaggttgcagtatgccgagatcacaccactgcactccagcctgggcaacaga
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate