Basic Information
VIS ID
TVIS10008396
Fusion event
HBV-NNT-AS1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
1961
Orient
-
Integrated sequence
CTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCC| |TTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATACT
Host Sequence
Chromosome
chr5
Cytoband
p12
Reference genome
GRCh37/hg19
Start
43600358/43600256 (Hg38)
End
43600358/43600256 (Hg38)
Orient
-
Location type
ncRNA_intronic
Target gene
NNT-AS1
Nearest miRNA
hsa-mir-10397/Upstream/5042695; hsa-mir-103a-1/Downstream/10351248;
Nearest TSS
ENST00000502646/Upstream/42498; ENST00000515208/Downstream/2436;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/42755, chr5-CpG: 62/Downstream/2619
Upstream sequence
CCTGGAATGTCTCACTCAGGACCATATGAGCTTCATCATCAACTTAGAGCCTCCTGTACTCATGTATGTTCTCACATCTATCTCAGAGGGACTCACTACT
Downstream sequence
tcctgacctcaggcaatccgcctgccttggccacaaagtgctgggattacaggcatgagccaccgcgcccggccAATTTTTTATATTGATTTAAAAACCC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate