ADAMTS6 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10008399
Fusion event
HBV-ADAMTS6 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|Polymerase|
Start
2380
Orient
-
Integrated sequence
CGCACTCCTCCAGCTTATAGACCACCAAATGCCCCTATCCTATCAACACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAA| |CTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATTCCTTGGACTCATAAGGTGGGGA
Host Sequence
Chromosome
chr5
Cytoband
q12.3
Reference genome
GRCh37/hg19
Start
64711643/65415816 (Hg38)
End
64711643/65415816 (Hg38)
Orient
+
Location type
Intronic
Target gene
ADAMTS6
miRNAs that regulate target gene
hsa-mir-148b-3p ; hsa-mir-221-3p
Nearest miRNA
hsa-mir-10397/Upstream/5712113; hsa-mir-103a-1/Downstream/6753651;
Nearest TSS
ENST00000502646/Upstream/152879; ENST00000508982/Downstream/57857;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/312427, chr5-CpG: 43/Downstream/147132
Upstream sequence
ggccttacccaaaagaaacatcaaatttcttataacttcccaacagcaggtacttttgcaatttggagtaatgcacctaccacagtcagtctcctctctt
Downstream sequence
AGCTCTCCATTGTCCCTGTGTGCACAGGCTACTGGGGGAACAAGATCAGCAAGCCCCACACCATCCCTTGCAAGGTGACAGGCCACTGCAGCTCTGTGCT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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