Basic Information
VIS ID
TVIS10008401
Fusion event
HBV-LOC101929380 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2037
Orient
-
Integrated sequence
TGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCT| |GAGCATTGTTCACCTCACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCTAGCTACCTGGGTGGGTGTTAATTTGGAAGATC
Host Sequence
Chromosome
chr5
Cytoband
q14.3
Reference genome
GRCh37/hg19
Start
86418346/87122529 (Hg38)
End
86418346/87122529 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC101929380
Nearest miRNA
hsa-mir-10397/Upstream/7575; hsa-mir-103a-1/Downstream/1544324;
Nearest TSS
ENST00000502646/Upstream/2381; ENST00000509953/Downstream/117261;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/2737744, chr5-CpG: 34/Downstream/145011
Nearby gene
MIR4280(-7575) ; RASA1(+145724) ;
Upstream sequence
AAAGACTGAAAGTGATGCTTTATGACTAAACTTTTGAAGAAATGAGACTATTCAAGTTGTTGAAGTCTTTGGAATCTGTGGTTAGCGTTAAGCAGACACT
Downstream sequence
tttcgtcttagaacttaacactatctgaaattagttgataaatatgtgtgcttacttcattcatctgtgtctcccaatgaggatgtaattttgaaaaagt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate