Basic Information
VIS ID
TVIS10008404
Fusion event
HBV-ZUP1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2018
Orient
+
Integrated sequence
ATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCG| |GGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCTAGCTACCTGGGTG
Host Sequence
Chromosome
chr6
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
116977435/116656272 (Hg38)
End
116977435/116656272 (Hg38)
Orient
+
Location type
Intronic
Target gene
ZUP1
miRNAs that regulate target gene
hsa-mir-203a-3p
Nearest miRNA
hsa-mir-10398/Upstream/9872052; hsa-mir-1202/Downstream/2412775;
Nearest TSS
ENST00000381078/Upstream/10014; ENST00000413340/Downstream/12522;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/84501, chr6-CpG: 53/Downstream/24663
Upstream sequence
catcaacagatgaatggataaagaaaaggtggtctgtatacacaatgaagtactattcagccatgaaaaaaaaagattcagtcatttgcaacaacattga
Downstream sequence
gggatttctccatgttggttaggctagtctcgaactcccgacctcaggtgatccgcctgtctcagcctcccaaagtgctgggattacaggcatgagccac
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate