Basic Information
VIS ID
TVIS10008405
Fusion event
HBV-LOC285766 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|middle S protein|
Start
40
Orient
-
Integrated sequence
AATTCCACAACCTTCCACCAAACTCTGCAAGATCCCAGAG| |TGAGAGGCCTGTATTTCCCTGCTGGTGGCTCCAGTTCAGGAACAGTAAACCCTGTTCTGACTACTGCCTCTCCCTTATCGTCAATCTTCTCGAGGATTGG
Host Sequence
Chromosome
chr6
Cytoband
p25.3
Reference genome
GRCh37/hg19
Start
192044/192044 (Hg38)
End
192044/192044 (Hg38)
Orient
+
Location type
Intronic
Target gene
LOC285766
Nearest miRNA
hsa-mir-10398/Downstream/1198270;
Nearest TSS
ENST00000381078/Downstream/11269;
Nearest CpG islands
None/Target, None/Upstream, chr6-CpG: 120/Downstream/99904
Nearby gene
DUSP22(+100057) ;
Upstream sequence
ttaaaacaattaaacccacagagatggagagtagaaggatggttacgagaggctgggaagagtagtagtggggggtgagagggagttgaggctatgtaaa
Downstream sequence
AGCAGGAAGGTACAGGGCTGTCCCTGCATGAGGAACTCACCGAGACCTGTACTTGTGTGACGGATGGTTCATACAAGTATTGAAGGTCCACATCACCAGC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate