Basic Information
VIS ID
TVIS10008406
Fusion event
HBV-chr6 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2122
Orient
-
Integrated sequence
GCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCTAGCTACCTGGGTGGGTG| |TTAATTTGGAAGATCCAGCGTCTAGAGACCTAGTAGTCAGTTATGTCAACACTAATATGGGCCTAAAGTTCAGGCAACTCTTGTGGTTTCACATTTCTTG
Host Sequence
Chromosome
chr6
Cytoband
p21.2
Reference genome
GRCh37/hg19
Start
37597935/37630159 (Hg38)
End
37597935/37630159 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA6H
Nearest miRNA
hsa-mir-1236/Upstream/74737; hsa-mir-10398/Downstream/1444155;
Nearest TSS
ENST00000381078/Upstream/85014; ENST00000469208/Downstream/9665;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/93644, chr6-CpG: 17/Downstream/18458
Nearby gene
MIR4462(-74737) ; MDGA1(+2349) ;
Upstream sequence
gaacatcacaaacacacatGGCAGCCCAGATCTCTTCACCTAGTCTTCCTCATACTTTTGGTATGAGGTTGCTCTACAAGAACCTAAAGAGGTAGGACAC
Downstream sequence
CTGTGCCCCTGGGAATGAATGGTCACTAGAGGAGGGGAGAAAGAGGGAAGATGCAAGGAGGTGTGTTTTcggtgcctgccagcctcctgcccctcctaag
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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