Basic Information
VIS ID
TVIS10008407
Fusion event
HBV-LOC100131047 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|Polymerase|
Start
2390
Orient
-
Integrated sequence
CAGCTTATAGACCACCAAATGCCCCTATCCTATCAACACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCC| |TCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATTCCTTGGACTCATAAGGTGGGGAACTTTACTGG
Host Sequence
Chromosome
chr6
Cytoband
p21.2
Reference genome
GRCh37/hg19
Start
38912793/38945017 (Hg38)
End
38912793/38945017 (Hg38)
Orient
+
Location type
ncRNA_intronic
Fragile sites / regions
FRA6H
Target gene
LOC100131047
Nearest miRNA
hsa-mir-1236/Upstream/1389595; hsa-mir-10398/Downstream/129297;
Nearest TSS
ENST00000381078/Upstream/12100; ENST00000373256/Downstream/8082;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/229528, chr6-CpG: 67/Downstream/103514
Upstream sequence
AATTAGCCCTGAAGTTCTATCAAGAAAAAAATTTCATCCCAGCTTTCTTACAACCTGTGCATGAATCAACCTCGTGCATTTCTGAAAGGATGAGACATCC
Downstream sequence
aaccctaacccATCCATGTCTTTATCTATCTGTTTGACCTGGTAACAAGTAGTTTTTAATGGCAAGCTTCTGGAGGAGTAATGACTAAGAAGTGATATTT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate