Basic Information
VIS ID
TVIS10008408
Fusion event
HBV-chr7 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|Polymerase|
Start
2390
Orient
-
Integrated sequence
CAGCTTATAGACCACCAAATGCCCCTATCCTATCAACACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCC| |TCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATTCCTTGGACTCATAAGGTGGGGAACTTTACTGG
Host Sequence
Chromosome
chr7
Cytoband
p22.3
Reference genome
GRCh37/hg19
Start
10080/10080 (Hg38)
End
10080/10080 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA7B
Nearest miRNA
hsa-mir-10399/Downstream/1012853;
Nearest TSS
ENST00000635602/Downstream/2624;
Nearest CpG islands
None/Target, None/Upstream, chr7-CpG: 39/Downstream/20923
Nearby gene
FAM20C(+182889) ;
Upstream sequence
ttttttcaccagatgccaaaaatagtgatttttattttttttttcagatggagtcttggtctgtcacccaggctggagtgcagtggtgcaatcttggctc
Downstream sequence
aacaaccctaaccctaaccctaaccctaaccctaaacctaaccctaaccctaaccctaacaaccctaaccctaaccctaaccctaaccctaacaacccta
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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