Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10008411
Fusion event
HBV-PRKAG2 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
precore/core protein|Core and e antigen|
Start
2166
Orient
+
Integrated sequence
CAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCTAGCTACCTGGGTGGGTGTTAATTTGGAAGATCCAGCGTCTAGAGACCTAGTAGTCAGTTAT| |GTCAACACTAATATGGGCCTAAAGTTCAGGCAACTCTTGTGGTTTCACATTTCTTGTCTCACTTTTGGAAGAGAAACAGTTATAGAGTATTTGGTGTCTT
Host Sequence
Chromosome
chr7
Cytoband
q36.1
Reference genome
End
151386181/151689095 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
Target gene
Nearest miRNA
hsa-mir-10399/Upstream/255456; hsa-mir-153-2/Downstream/5885241;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/55993, chr7-CpG: 33/Downstream/35487
Upstream sequence
TTTAAAATTTTGGGGTCGAATACATATATTTAAGAAAATACATAAAGGTCACTTTTAAAAGTTGCATTTGggccaggcatgctggctcacgcttgtaatc
Downstream sequence
TAAAGCTTCCAGAGCATAGTCGTTTTTAAAATCTGTAATAGTACCTGGAGTTTTTTCCTGTGCTTTCTATAATTCAGCTCTTTGAGTCTGCTCTGAACCC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.