Basic Information
VIS ID
TVIS10008412
Fusion event
HBV-chr7 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|
Start
3171
Orient
-
Integrated sequence
CAAACTTTGCCAGCAAATCCGCCTCCTGCCTCCACCAATCGCCAGTCAGGAAGGCAGCCTACCCCGCTGTCTCCACCTTTGAGAAACACTCATCCTCAGG| |CCATGCAGTGG
Host Sequence
Chromosome
chr7
Cytoband
p22.3
Reference genome
GRCh37/hg19
Start
434981/395015 (Hg38)
End
434981/395015 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA7B
Nearest miRNA
hsa-mir-10399/Downstream/627918;
Nearest TSS
ENST00000635602/Upstream/15656; ENST00000452622/Downstream/101103;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/2625, chr7-CpG: 47/Downstream/26138
Nearby gene
LOC442497(-12136) ; PDGFA(+101916) ;
Nearest cancer related gene
PDGFA(OG, +101916) ;
Upstream sequence
tacatcagctaacaggcaaaataaccagctagcatcataatgacagggtcaaattcacacataacagtattagccttaaacgtaaatgggctaaatgccc
Downstream sequence
tagccaggtttagtgacacatgcctgtgatcccagcttctcaggaggctgaggtgggaggatcacttgagcctgggagttcaaggctgcagtgggctgtg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate