Basic Information
VIS ID
TVIS10008413
Fusion event
HBV-chr7 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
Polymerase|large S protein|middle S protein|
Start
146
Orient
-
Integrated sequence
GCCTGTATTTCCCTGCTGGTGGCTCCAGTTCAGGAACAGTAAACCCTGTTCTGACTACTGCCTCTCCCTTATCGTCAATCTTCTCGAGGATTGGGGACCC| |TGCGCTGAACATGGAGAACATCACATCAGGATTCCTAGGACCCCTTCTCGTGTTACAGGCGGGGTTTTTCTTGTTGACAAGAATCCTCACAATACCGCAG
Host Sequence
Chromosome
chr7
Cytoband
p22.3
Reference genome
End
435233/395267 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
Nearest miRNA
hsa-mir-10399/Downstream/627666;
Nearest CpG islands
Nearby gene
LOC442497(-12388) ; PDGFA(+101664) ;
Nearest cancer related gene
PDGFA(OG, +101664) ;
Upstream sequence
caaattcacacataacagtattagccttaaacgtaaatgggctaaatgccccaattaaaagacacagactgccaaattgaataaagagacaagacctatt
Downstream sequence
tttccttatttgccacgtctggttctctttgttgcatcctgtggattccagtcacctctgagcaccgttgcctcactctgatacagcttcatatctgcca
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate