AUTS2 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10008415
Fusion event
HBV-AUTS2 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
1973
Orient
+
Integrated sequence
CCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTT| |TCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATACTGCACTCAGGCAA
Host Sequence
Chromosome
chr7
Cytoband
q11.22
Reference genome
GRCh37/hg19
Start
69802798/70337812 (Hg38)
End
69802798/70337812 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA7J
Target gene
AUTS2
miRNAs that regulate target gene
hsa-mir-21-5p ; hsa-mir-222-3p ; hsa-mir-218-5p
Nearest miRNA
hsa-mir-1183/Upstream/3223415; hsa-mir-10399/Downstream/969860;
Nearest TSS
ENST00000635602/Upstream/20896; ENST00000489774/Downstream/258273;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/737761, chr7-CpG: 64/Downstream/258036
Upstream sequence
agaagtttttaggtgccagtggaagtcagtctcttatttacatgtctggttctaaaaccagctctttccaatggtgtgcacaaataaattactttaggta
Downstream sequence
TATCATTGCCATGAGGATCAGTCCCTGAGGCCTTGCTCTCTGCCTCAGTTTACTGTTGTTGGAAGCTATGATTCTTTTCCACAATGGGCTTGCAGTGTAG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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