Basic Information
VIS ID
TVIS10008420
Fusion event
HBV-chr8 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|middle S protein|
Start
136
Orient
+
Integrated sequence
AGAGTGAGAGGCCTGTATTTCCCTGCTGGTGGCTCCAGTTCAGGAACAGTAAACCCTGTTCTGACTACTGCCTCTCCCTTATCGTCAATCTTCTCGAGGA| |TTGGGGACCCTGCGCTGAACATGGAGAACATCACATCAGGATTCCTAGGACCCCTTCTCGTGTTACAGGCGGGGTTTTTCTTGTTGACAAGAATCCTCAC
Host Sequence
Chromosome
chr8
Cytoband
q21.13
Reference genome
GRCh37/hg19
Start
77793630/76881394 (Hg38)
End
77793630/76881394 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-124-1/Upstream/2175647; hsa-mir-10400/Downstream/85374;
Nearest TSS
ENST00000518652/Upstream/31594; ENST00000519660/Downstream/23197;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/198769, chr8-CpG: 78/Downstream/118502
Nearby gene
ZFHX4(-14109) ; PEX2(+98864) ;
Upstream sequence
tgttgcccaggctggagtgtagtggcgcgatctcagctcactgcaacttccaccttctggtttcaagtgattctcctgcctcagcctcccgagtagctgg
Downstream sequence
aaagtgagagaaactgagctcaaagagatgaaccatgattcatattcaggttttcttccttacaaaTGATATTTATTGTGGGTTGACtgtgtgtgtgtgt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate