Basic Information
VIS ID
TVIS10008423
Fusion event
HBV-LOC340512 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2229
Orient
-
Integrated sequence
GGAAGATCCAGCGTCTAGAGACCTAGTAGTCAGTTATGTCAACACTAATATGGGCCTAAAGTTCAGGCAACTCTTGTGGTTTCACATTTCTTGTCTCACT| |TTTGGAAGAGAAACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCTCCAGCTTATAGACCACCAAATGCCCCTATCCTATCAACAC
Host Sequence
Chromosome
chr9
Cytoband
q31.2
Reference genome
GRCh37/hg19
Start
109851426/107089145 (Hg38)
End
109851426/107089145 (Hg38)
Orient
+
Location type
Intronic
Target gene
LOC340512
Nearest miRNA
hsa-let-7a-1/Upstream/488123; hsa-mir-12126/Downstream/1957084;
Nearest TSS
ENST00000422679/Upstream/79956; ENST00000442587/Downstream/13727;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/228223, chr9-CpG: 125/Downstream/193686
Nearby gene
MIR548Q(-2710) ; RAD23B(+194091) ;
Upstream sequence
TATTGTCCAATTAGTTAGGGTTCCTTAGTTTCTAAGAACAGCACTCAATGGATTTAAAACAGACTGGCAGGCCTGGGAGGGGCCGTGGCCCCTAATTGGA
Downstream sequence
aaacaacacagcttctccttcctttgttgaagtagtgtcagaggaagccagctaaaatggacagcttaaacgagacccatagtctcataatacagtagca
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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