Basic Information
VIS ID
TVIS10008435
Fusion event
HBV-chrX integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
593
Orient
-
Integrated sequence
CCTCAACAACCAGCACGGGACCATGCCGGACCTGCATGACTACTGCTCAAGGAACCTCTATGTATCCCTCCTGTTGCTGTACCAAACCTTCGGACGGAAA| |TTGCACCTGTATTCCCATCCCATCATCCTGGGCTTTCGGAAAATTCCTATGGGAGTGGGCCTCAGCCCGTTTCTCCTGGCTCAGTTTACTAGTGCCATTT
Host Sequence
Chromosome
chrX
Cytoband
q11.1
Reference genome
GRCh37/hg19
Start
62226276/63006806 (Hg38)
End
62226276/63006806 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-let-7f-2/Upstream/7555224; hsa-mir-105-1/Downstream/779196;
Nearest TSS
ENST00000429181/Upstream/5095986; ENST00000451979/Downstream/342840;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/5096319, chrX-CpG: 51/Downstream/344267
Nearby gene
SPIN4(+340831) ;
Upstream sequence
ttgaaaagggctgatttagtgctatgcctgttttttgtggtatgagggagcagatacagcaacttatgttttaccttaggagggctatttcaacatgccc
Downstream sequence
ttctggctaagactttgagtactgtgttgactaaaagcgatgatagtgggcattcttgtctttttccaggtcttagagaaaattctttcaattagtttac
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate