Basic Information
VIS ID
TVIS10008453
Fusion event
HBV-chr16 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2018
Orient
+
Integrated sequence
ATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCG| |GGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCTAGCTACCTGGGTG
Host Sequence
Chromosome
chr16
Cytoband
q12.1
Reference genome
GRCh37/hg19
Start
47795295/47761384 (Hg38)
End
47795295/47761384 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-1225/Upstream/13597711; hsa-mir-11401/Downstream/2531232;
Nearest TSS
ENST00000527434/Upstream/36816; ENST00000569726/Downstream/97195;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/300088, chr16-CpG: 31/Downstream/483037
Nearby gene
PHKB(-59861) ; ABCC12(+321589) ;
Upstream sequence
aggttcaagcgattctcctgcctcagcctcctgagtagctggggttacaggcatgtgccaccatggctggctaattttgtaatttttttttagtagagat
Downstream sequence
gggatttctccgtgttggtcaggctggtctccaactcctgatctcaggtgatccacctgcctcagcctcccaaagtgctgggattacaggcatgagccac
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate