Basic Information
VIS ID
TVIS10008454
Fusion event
HBV-chr2 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1667
Orient
-
Integrated sequence
TCTGCCGGACCGTGTGCACTTCGCTTCACCTCTGCACGTCGCATGGAGACCACCGTGAACGCCCACCAAATATTGCCCAAGGTCTTACATAAGAGGACTC| |TTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGT
Host Sequence
Chromosome
chr2
Cytoband
q12.1
Reference genome
GRCh37/hg19
Start
102866106/102249646 (Hg38)
End
102866106/102249646 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA2S ; FRA2A
Nearest miRNA
hsa-mir-1285-2/Upstream/940112; hsa-mir-10b/Downstream/182643;
Nearest TSS
ENST00000437798/Upstream/62332; ENST00000447231/Downstream/61856;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/61550, chr2-CpG: 62/Downstream/987
Nearby gene
IL1RL2(-10295) ; IL1RL1(+61856) ;
Upstream sequence
aatttggtttctgtttctcacaatggaaataatcctaacaaatacaAGCCTCAATATGTTAGTCTTTTCCTGCAGACTTCTTTCTGATTGATATCACTGT
Downstream sequence
AGCAATGTGAATTTTTCTATGAAATCATGTAAGTTTCTCTCCTTGGAAAAGAGATTAAAAAGCCATACTAGGTTTGGGGTTCCTATCATAAGTGTGTTTG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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