Basic Information
VIS ID
TVIS10008457
Fusion event
HBV-IGK integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
676
Orient
-
Integrated sequence
AAACCTTCGGACGGAAATTGCACCTGTATTCCCATCCCATCATCCTGGGCTTTCGGAAAATTCCTATGGGAGTGGGCCTCAGCCCGTTTCTCCTGGCTCA| |GTTTACTAGTGCCATTTGTTCAGTGGTTCGTAGGGCTTTCCCCCACTGTTTGGCTTTCAGTTATATGGATGATGTGGTATTGGGGGCCAAGTCTGTACAG
Host Sequence
Chromosome
chr2
Cytoband
p11.2
Reference genome
GRCh37/hg19
Start
89872213/89833403 (Hg38)
End
89872213/89833403 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA2S ; FRA2L
Target gene
IGK
Nearest miRNA
hsa-mir-1285-2/Upstream/1020949; hsa-mir-10b/Downstream/6964875;
Nearest TSS
ENST00000437798/Upstream/502974; ENST00000429992/Downstream/18388;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/65302, chr2-CpG: 65/Downstream/404645
Nearby gene
MIR4436A(-760245) ; LSP1P4(+1952496) ;
Upstream sequence
attccattccattccattccattccattccactcgtgttgattccattccattccattcaactccgttccattccattccattccattccattccattcc
Downstream sequence
attccattccactcagattgattccattccatttcattccattccactccattccattcgaatactttccactcgggttgattgcattccatttcattcc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate