Basic Information
VIS ID
TVIS10008458
Fusion event
HBV-chr4 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
2804
Orient
+
Integrated sequence
TATCCAGAACATCTAGTTAATCATTACTTCCAAACTAGACACTATTTACACACTCTATGGAAGGCGGGTATATTATATAAGAGAGAAACAACACATAGCG| |CCTCATTTTGTGGGTCACCATATTCTTGGGAACAAGATCTACAGCATGGGGCAGAATCTTTCCACCAGCAATCCTCTGGGATTCTTTCCCGACCACCAGT
Host Sequence
Chromosome
chr4
Cytoband
p16.3
Reference genome
GRCh37/hg19
Start
21049/21049 (Hg38)
End
21049/21049 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-12113/Downstream/329108;
Nearest TSS
ENST00000502981/Downstream/32236;
Nearest CpG islands
None/Target, None/Upstream, chr4-CpG: 46/Downstream/32255
Nearby gene
ZNF595(+32178) ;
Upstream sequence
CTAGCCTCAAATTATATTTTTAATTTCAAATATAAGCAACATTGAAAGAAAGTAGAAAGAAACAAACCTATAATCTTCTGTTCTAACACTACTATGCTTA
Downstream sequence
tttttttttttttttttttggtaatttctgtgtaagtaaaaaaaaaagatgtaaaataaaactttatttaaaaCCTTTTTATATTTTTTAATGCTTCCTT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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