Basic Information
VIS ID
TVIS10008463
Fusion event
HBV-LOC101928354 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
2498
Orient
-
Integrated sequence
GAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATTCCTTGGACTCATAAGGTGGGGAACTTTACTGGGCTTTATT| |CTTCTACTGTACCTGTCTTTAATCCTCATTGGAAAACACCATCTTTTCCTAATATACATTTACACCAAGACATTATCAAAAAATGTGAACAGTTTGTAGG
Host Sequence
Chromosome
chr6
Cytoband
p23
Reference genome
GRCh37/hg19
Start
14575770/14575539 (Hg38)
End
14575770/14575539 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA6A
Target gene
LOC101928354
Nearest miRNA
hsa-mir-3691/Upstream/4135745; hsa-mir-10398/Downstream/1566017;
Nearest TSS
ENST00000381078/Upstream/181213; ENST00000474854/Downstream/24151;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/364026, chr6-CpG: 113/Downstream/669107
Nearby gene
CD83(-438622) ; JARID2(+670436) ;
Upstream sequence
ATATAATGTAACTCACAATTCAGGCAGTACTGTTGGACCATGTTATAACCTAGATAAATACAGCCTAGGTTACTTTGTTTCCCAAAACATATAATTACAG
Downstream sequence
CCTGACAGAAGTAGGTTGAGGGACAATGGTCACAGCATGGAGGGCTTCGCAAGAAGGCTGGCAGGGCAGCCACGAGAACAGGAGAGTCAAGGGCAACATG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate