VISDB Viral Integration Site DataBase

VIS ID

TVIS10008470

Fusion event

HBV-SV2B integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

S protein|Polymerase|large S protein|middle S protein|

Start

536

Orient

+

Integrated sequence

TGTTGGTTCTTCTGGACTATCAAGGTATGTTGCCCGTTTGTCCTCTAATTCCAGGATCCTCAACAACCAGCACGGGACCATGCCGGACCTGCATGACTAC| |TGCTCAAGGAACCTCTATGTATCCCTCCTGTTGCTGTACCAAACCTTCGGACGGAAATTGCACCTGTATTCCCATCCCATCATCCTGGGCTTTCGGAAAA

Chromosome

chr15

Cytoband

q26.1

Reference genome

Start

End

91757981/91214751 (Hg38)

Orient

-

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-26b-5p ; hsa-mir-574-5p ; hsa-mir-297 ; hsa-mir-3924 ; hsa-mir-190a-3p ; hsa-mir-6867-5p ; hsa-mir-223-5p ; hsa-mir-567 ; hsa-mir-5011-5p ; hsa-mir-6842-3p ; hsa-mir-647 ; hsa-mir-524-5p ; hsa-mir-520d-5p ; hsa-mir-6762-3p ; hsa-mir-604 ; hsa-mir-3130-3p ; hsa-mir-6071 ; hsa-mir-8077 ; hsa-mir-7160-5p ; hsa-mir-4663 ; hsa-mir-3692-5p ; hsa-mir-27b-5p ; hsa-mir-93-3p ; hsa-mir-6728-3p ; hsa-mir-4714-3p ; hsa-mir-4789-5p ; hsa-mir-8066 ; hsa-mir-4803 ; hsa-mir-3941 ; hsa-mir-603 ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-8485 ; hsa-mir-6848-3p ; hsa-mir-6843-3p ; hsa-mir-6716-5p ; hsa-mir-4790-3p ; hsa-mir-4518 ; hsa-mir-1266-5p ; hsa-mir-3664-3p ; hsa-mir-6754-5p ; hsa-mir-4441 ; hsa-mir-4270 ; hsa-mir-211-3p

Nearest miRNA

hsa-mir-10393/Upstream/1207910; hsa-mir-1302-10/Downstream/1689648;

Nearest TSS

Nearest CpG islands

None/Target, chr15-CpG: 55/Upstream/114279, chr15-CpG: 40/Downstream/81967

Upstream sequence

TATCATTAACAATTGTTTTCCCGATGAAATCAAAACGAAGTAGGATTGGCAAGCTGCCCATAATTGGTCTTTGTTAGGGCTTCCTTCCCCATTCCACTGG

Downstream sequence

CTCACTTATTTAAGTGTTCCCCAAACAGTTGTGGGGGGTGTGCTTGACTCCTTAGTCCATGGCTATAGCCACAGTGGTTCTCCTCGTTCTTTCTGCTCCT