Basic Information
VIS ID
TVIS10008472
Fusion event
HBV-SLC47A1P1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1818
Orient
-
Integrated sequence
GTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATG| |CAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTT
Host Sequence
Chromosome
chr17
Cytoband
p11.2
Reference genome
GRCh37/hg19
Start
19494011/19590698 (Hg38)
End
19494011/19590698 (Hg38)
Orient
+
Location type
Intronic
Target gene
SLC47A1P1
Nearest miRNA
hsa-mir-1180/Upstream/246124; hsa-mir-10226/Downstream/7703212;
Nearest TSS
ENST00000595228/Upstream/17901; ENST00000580550/Downstream/7224;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/10324, chr17-CpG: 100/Downstream/57333
Nearby gene
SLC47A1(-11665) ; ALDH3A2(+58053) ;
Upstream sequence
CCCTAGCATTGTCTCATGTGAGTGAGGTTCTCTGAGATCATACATCAAGGGGAAGTGTCTTATTTAAGATTAAAAACCGGAACTAAACTAAACCGTTGGA
Downstream sequence
ATTTATATTAATGAGAAGTGTTTGTTTTTCTGTTTAAACTTACAGGCAGCATTCTTGTTCCAGCTGCAGACAAGATATTTACAAAGTCAGGTATAGATTC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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