Basic Information
VIS ID
TVIS10008479
Fusion event
HBV-IL37 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
325
Orient
+
Integrated sequence
AGAATCCTCACAATACCGCAGAGTCTAGACTCGTGGTGGACTTCTCTCAATTTTCTAGGGGGAACTACCGTGTGTCTTGGCCAAAATTCGCAGTCCCCAA| |CCTCCAATCACTCACCAACCTCTTGTCCTCCAACTTGTCCTGGTTATCGCTGGATGTGTCTGCGGCGTTTTATCATCTTCCTCTTCATCCTGCTGCTATG
Host Sequence
Chromosome
chr2
Cytoband
q14.1
Reference genome
GRCh37/hg19
Start
113669959/112912382 (Hg38)
End
113669959/112912382 (Hg38)
Orient
+
Location type
upstream
Fragile sites / regions
FRA2S ; FRA2B
Target gene
IL37
miRNAs that regulate target gene
hsa-mir-335-5p
Nearest miRNA
hsa-mir-1285-2/Upstream/1141248; hsa-mir-10b/Downstream/670577;
Nearest TSS
ENST00000437798/Upstream/75479; ENST00000263326/Downstream/589;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/147385, chr2-CpG: 21/Downstream/138558
Upstream sequence
aatttatatatataaatatatCTCCTCCAACCCCTCCCAATGAAGCAAGTCACGTGAGTCAATCCTACCCTAAGATATTAGGGATTGAGCCTCCTGGGAC
Downstream sequence
ATTTGGTGGCTTAGGTTTTCATGAAAAGAGGTTGCAGAGCAACTGCTTTTTGTTAGGCAAAGATTAGGCTACTGcagagactcagcaaacttctatagaa
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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