Basic Information
VIS ID
TVIS10008481
Fusion event
HBV-chr2 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
653
Orient
-
Integrated sequence
TGTATCCCTCCTGTTGCTGTACCAAACCTTCGGACGGAAATTGCACCTGTATTCCCATCCCATCATCCTGGGCTTTCGGAAAATTCCTATGGGAGTGGGC| |CTCAGCCCGTTTCTCCTGGCTCAGTTTACTAGTGCCATTTGTTCAGTGGTTCGTAGGGCTTTCCCCCACTGTTTGGCTTTCAGTTATATGGATGATGTGG
Host Sequence
Chromosome
chr2
Cytoband
q31.1
Reference genome
GRCh37/hg19
Start
174373351/173508623 (Hg38)
End
174373351/173508623 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA2G
Nearest miRNA
hsa-mir-128-1/Upstream/4925605; hsa-mir-10b/Downstream/1659010;
Nearest TSS
ENST00000437798/Upstream/150116; ENST00000604994/Downstream/302453;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/152983, chr2-CpG: 54/Downstream/454979
Nearby gene
CDCA7(-139633) ; SP3(+397836) ;
Upstream sequence
cacctctttcttccccaggcctttgatcccctactggtgcctccattggtcaaaaccaaccagagccagctgataagaaagtccaagtgatacagttcat
Downstream sequence
gggccctcagtccagggcctagagaagggtaaggaaggatgaagaatgaagctgagttgggagtggaggcaaacagaggataGATGATTCACTGCTTATC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate