Basic Information
VIS ID
TVIS10008486
Fusion event
HBV-LOC110806263 integration
Validated
Yes
Detection method
PCR and Sanger sequencing
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
Polymerase|large S protein|middle S protein|
Start
116
Orient
+
Integrated sequence
ACCAAACTCTGCAAGATCCCAGAGTGAGAGGCCTGTATTTCCCTGCTGGTGGCTCCAGTTCAGGAACAGTAAACCCTGTTCTGACTACTGCCTCTCCCTT| |ATCGTCAATCTTCTCGAGGATTGGGGACCCTGCGCTGAACATGGAGAACATCACATCAGGATTCCTAGGACCCCTTCTCGTGTTACAGGCGGGGTTTTTC
Host Sequence
Chromosome
chr5
Cytoband
p15.33
Reference genome
End
1296775/1296660 (Hg38)
Orient
+
Location type
Intronic
Target gene
Nearest miRNA
hsa-mir-4635/Upstream/233686; hsa-mir-10397/Downstream/12650;
Nearest CpG islands
Nearby gene
TERT(-1613) ; MIR4457(+12650) ;
Upstream sequence
AGAGATTCAGAACACCTAGGTTTCATAGTTCTTGTGGCGCATGAGCCTTTGTGTGATTTAGTTTGTCATCCTTCTCTGTCCTTCCGTCTTATTCCTATCC
Downstream sequence
CACCCCAGTATTATGGGTGCAGTTAGTGTGTCTTTGAAAAGCTGATGATGTCTTAGTCATCACAGTGTAAAACATCAAGAGTGTTCTAACAACAATAAAA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate