Fusion event
HBV-LOC110806263 integration
Detection method
PCR and Sanger sequencing
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Region type
Polymerase|large S protein|middle S protein|
Integrated sequence
ACCAAACTCTGCAAGATCCCAGAGTGAGAGGCCTGTATTTCCCTGCTGGTGGCTCCAGTTCAGGAACAGTAAACCCTGTTCTGACTACTGCCTCTCCCTT| |ATCGTCAATCTTCTCGAGGATTGGGGACCCTGCGCTGAACATGGAGAACATCACATCAGGATTCCTAGGACCCCTTCTCGTGTTACAGGCGGGGTTTTTC
End
1296775/1296660 (Hg38)
Nearest miRNA
hsa-mir-4635/Upstream/233686; hsa-mir-10397/Downstream/12650;
Upstream sequence
AGAGATTCAGAACACCTAGGTTTCATAGTTCTTGTGGCGCATGAGCCTTTGTGTGATTTAGTTTGTCATCCTTCTCTGTCCTTCCGTCTTATTCCTATCC
Downstream sequence
CACCCCAGTATTATGGGTGCAGTTAGTGTGTCTTTGAAAAGCTGATGATGTCTTAGTCATCACAGTGTAAAACATCAAGAGTGTTCTAACAACAATAAAA
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.