Basic Information
VIS ID
TVIS10008496
Fusion event
HBV-chr10 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1817
Orient
+
Integrated sequence
TGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCAT| |GCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCT
Host Sequence
Chromosome
chr10
Cytoband
q25.3
Reference genome
GRCh37/hg19
Start
118073280/116313768 (Hg38)
End
118073280/116313768 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA10D ; FRA10A ; FRA10B
Nearest miRNA
hsa-mir-107/Upstream/2139589; hsa-mir-202/Downstream/513720;
Nearest TSS
ENST00000439456/Upstream/40301; ENST00000463594/Downstream/10660;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/39050, chr10-CpG: 57/Downstream/295299
Nearby gene
GFRA1(-40154) ; CCDC172(+10660) ;
Upstream sequence
AATACACTGAATTCAGTATTGGTTTCTAGCATTTTCTAGTTATTAAAATGAACACTTAAATGTTCATTGTTTAGACCAAAAACTATTGTTCATGCCAACC
Downstream sequence
CTTGCATACATTCATTTTCCTTTattcattcatctgacacaaagtcattgggaaattgctgtttccctgatactgttctaggggctgggaatcagtggtg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate