VISDB Viral Integration Site DataBase

VIS ID

TVIS10008499

Fusion event

HBV-TMEM132B integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

precore/core protein|Core and e antigen|

Start

2206

Orient

+

Integrated sequence

GCTACCTGGGTGGGTGTTAATTTGGAAGATCCAGCGTCTAGAGACCTAGTAGTCAGTTATGTCAACACTAATATGGGCCTAAAGTTCAGGCAACTCTTGT| |GGTTTCACATTTCTTGTCTCACTTTTGGAAGAGAAACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCTCCAGCTTATAGACCACC

Chromosome

chr12

Cytoband

q24.32

Reference genome

Start

End

126105453/125620907 (Hg38)

Orient

-

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-221-3p ; hsa-mir-181a-5p ; hsa-mir-297 ; hsa-mir-3924 ; hsa-mir-567 ; hsa-mir-602 ; hsa-mir-8485 ; hsa-mir-377-3p ; hsa-mir-744-3p ; hsa-mir-6848-3p ; hsa-mir-6843-3p ; hsa-mir-378a-5p ; hsa-mir-4423-5p ; hsa-mir-6501-5p ; hsa-mir-6131 ; hsa-mir-6505-3p ; hsa-mir-617 ; hsa-mir-3663-5p ; hsa-mir-3653-5p ; hsa-mir-372-5p ; hsa-mir-371a-5p ; hsa-mir-616-5p ; hsa-mir-373-5p ; hsa-mir-371b-5p ; hsa-mir-3934-5p ; hsa-mir-764 ; hsa-mir-125a-3p ; hsa-mir-505-3p ; hsa-mir-4735-5p ; hsa-mir-4762-5p ; hsa-mir-1208 ; hsa-mir-1273f ; hsa-mir-1291 ; hsa-mir-1304-3p ; hsa-mir-328-3p ; hsa-mir-4290 ; hsa-mir-4469 ; hsa-mir-6760-3p ; hsa-mir-6775-3p ; hsa-mir-6851-3p

Nearest miRNA

hsa-let-7i/Upstream/705248; hsa-mir-3612/Downstream/2673185;

Nearest TSS

Nearest CpG islands

None/Target, chr12-CpG: 104/Upstream/87088, chr12-CpG: 24/Downstream/62987

Upstream sequence

cagatcttgtgagaactcacttactatcacaagaatagcagcatgagagtaactgccccaatgattccattgcctcccactgagtccctccaatgacatg

Downstream sequence

tggggattatgggaactacaattcaagttgagatttggttggggacacagccaaaccatatcaCACAGACAACTGAACTTTGGGAGACTTGGCCCAAGAT