VISDB Viral Integration Site DataBase

VIS ID

TVIS10008510

Fusion event

HBV-NWD1 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

S protein|Polymerase|large S protein|middle S protein|

Start

767

Orient

-

Integrated sequence

CCTGGCTCAGTTTACTAGTGCCATTTGTTCAGTGGTTCGTAGGGCTTTCCCCCACTGTTTGGCTTTCAGTTATATGGATGATGTGGTATTGGGGGCCAAG| |TCTGTACAGCATCTTGAGTCCCTTTTTACCGCTGTTACCAATTTTCTTTTGTCTTTGGGTATACATTTAAACCCTAACAAAACAAAGAGATGGGGTTACT

Chromosome

chr19

Cytoband

p13.11

Reference genome

Start

End

16890542/16779731 (Hg38)

Orient

-

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-140-3p ; hsa-mir-497-3p ; hsa-mir-935 ; hsa-mir-548t-3p ; hsa-mir-548aa ; hsa-mir-548ap-3p ; hsa-mir-3149 ; hsa-mir-411-5p ; hsa-mir-6832-5p ; hsa-mir-6770-5p ; hsa-mir-6504-5p ; hsa-mir-3064-5p ; hsa-mir-29a-5p ; hsa-mir-3123 ; hsa-mir-3925-5p ; hsa-mir-3154 ; hsa-mir-548v ; hsa-mir-548d-3p ; hsa-mir-548au-3p ; hsa-mir-3680-3p ; hsa-mir-557 ; hsa-mir-507 ; hsa-mir-450b-5p ; hsa-mir-500a-3p ; hsa-mir-767-5p ; hsa-mir-5003-3p ; hsa-mir-5197-5p ; hsa-mir-498 ; hsa-mir-4279 ; hsa-mir-4284 ; hsa-mir-6778-3p ; hsa-mir-4772-3p ; hsa-mir-4638-5p ; hsa-mir-1976 ; hsa-mir-3653-5p ; hsa-mir-6741-3p ; hsa-mir-1281 ; hsa-mir-4485-5p ; hsa-mir-4532 ; hsa-mir-1247-3p ; hsa-mir-6890-3p ; hsa-mir-1228-3p ; hsa-mir-640 ; hsa-mir-4297 ; hsa-mir-5581-5p ; hsa-mir-6821-3p ; hsa-mir-6790-3p ; hsa-mir-7107-5p ; hsa-mir-1234-3p ; hsa-mir-6747-3p ; hsa-mir-3934-5p ; hsa-mir-764 ; hsa-mir-125a-3p ; hsa-mir-378a-5p ; hsa-mir-4465 ; hsa-mir-26b-5p ; hsa-mir-26a-5p ; hsa-mir-1297 ; hsa-mir-345-5p ; hsa-mir-6513-3p ; hsa-mir-8062 ; hsa-mir-129-5p ; hsa-mir-4776-3p ; hsa-mir-4659b-5p ; hsa-mir-5590-5p ; hsa-mir-4659a-5p ; hsa-mir-548aw ; hsa-mir-1273g-5p ; hsa-mir-203a-5p ; hsa-mir-1468-3p ; hsa-mir-548x-5p ; hsa-mir-548g-5p ; hsa-mir-548f-5p ; hsa-mir-548aj-5p ; hsa-mir-885-5p

Nearest miRNA

hsa-mir-10395/Upstream/1330123; hsa-let-7e/Downstream/1502346;

Nearest TSS

Nearest CpG islands

None/Target, chr19-CpG: 112/Upstream/117910, chr19-CpG: 20/Downstream/27916

Upstream sequence

acaagccatttctttttctttttaaatatgggatctcactgtattgcccaggctggagtgcagtggtgtgtttataactcactgcagcctcaaactcctg

Downstream sequence

ggccaagtgatcctcctgcctcagcctcctgagtagctgggactacaagcacataccactatacccagctaattttttaatgtttttagaaatggggtct