Basic Information
VIS ID
TVIS10008511
Fusion event
HBV-chr2 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|Polymerase|
Start
2322
Orient
+
Integrated sequence
TCTCACTTTTGGAAGAGAAACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCTCCAGCTTATAGACCACCAAATGCCCCTATCCTA| |TCAACACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCA
Host Sequence
Chromosome
chr2
Cytoband
q14.3
Reference genome
GRCh37/hg19
Start
127044943/126287366 (Hg38)
End
127044943/126287366 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA2S
Nearest miRNA
hsa-mir-1285-2/Upstream/12565998; hsa-mir-10b/Downstream/1136171;
Nearest TSS
ENST00000437798/Upstream/169381; ENST00000419223/Downstream/21144;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/2261688, chr2-CpG: 51/Downstream/368754
Nearby gene
CNTNAP5(-1372080) ; GYPC(+368568) ;
Upstream sequence
ttttacctctagaaatcctaccaggttcttacaatgaggaccagagaaatatttccttgtcgctttttcaggggaagggaaagagaaaccattgtgaaat
Downstream sequence
gctcagagtggtatacataaccaaagactgcatgccagaggaaaatacttttaccagagctttatcccatctggggaaaggtcatttctcccactccacc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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