Basic Information
VIS ID
TVIS10008515
Fusion event
HBV-chr2 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2061
Orient
+
Integrated sequence
TTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATACT| |GCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCTAGCTACCTGGGTGGGTGTTAATTTGGAAGATCCAGCGTCTAGAGACCTAGTAGTCA
Host Sequence
Chromosome
chr2
Cytoband
q34
Reference genome
GRCh37/hg19
Start
211558969/210694245 (Hg38)
End
211558969/210694245 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-10b/Upstream/2939364; hsa-mir-1244-1/Downstream/1732018;
Nearest TSS
ENST00000437798/Upstream/22630; ENST00000434559/Downstream/971109;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/217433, chr2-CpG: 86/Downstream/1843211
Nearby gene
CPS1(-15138) ; ERBB4(+681473) ;
Nearest cancer related gene
ERBB4(OG, +681473) ;
Upstream sequence
cacagccaaactctgcttaaggtgtggaaagagacctcacctctcaatgggaATATTCACATGCACATTTTCCTTCTTGATGTGCAGTTTCATGTACTTT
Downstream sequence
GAAAAATTAACTTGCAGAAGTTTTAATATACAGAGGAAATTGGGCCTTTGTTCATTATTTATATCTCAATTATTTTTTCCATTTTGATTTTCGTTGTTTT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate