Basic Information
VIS ID
TVIS10008521
Fusion event
HBV-UQCC1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
1923
Orient
+
Integrated sequence
TTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAA| |GAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAG
Host Sequence
Chromosome
chr20
Cytoband
q11.22
Reference genome
GRCh37/hg19
Start
33976097/35388294 (Hg38)
End
33976097/35388294 (Hg38)
Orient
+
Location type
Intronic
Target gene
UQCC1
miRNAs that regulate target gene
hsa-mir-24-3p ; hsa-mir-1226-3p
Nearest miRNA
hsa-mir-103a-2/Upstream/397797; hsa-mir-1-1/Downstream/65660;
Nearest TSS
ENST00000382410/Upstream/41068; ENST00000374375/Downstream/5909;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/95882, chr20-CpG: 41/Downstream/45915
Upstream sequence
tggtctcaaactcctgacctcaagtgatcagcccaccttagcctcccaaagtgctggtattacaggcatgagccaccacacctgcccCTTCTAtttcttt
Downstream sequence
ttttctttttttttgagacagggtcttgctctgtcacccaggctggagtacagtggtgtggtcatgggtcactgcaactttgacccccccagactcaagg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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