Basic Information
VIS ID
TVIS10008523
Fusion event
HBV-LOC105372676 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1827
Orient
-
Integrated sequence
AAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTT| |CACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAAT
Host Sequence
Chromosome
chr20
Cytoband
q13.2
Reference genome
GRCh37/hg19
Start
54175462/55600404 (Hg38)
End
54175462/55600404 (Hg38)
Orient
+
Location type
Intronic
Target gene
LOC105372676
Nearest miRNA
hsa-mir-103a-2/Upstream/1531919; hsa-mir-1-1/Downstream/1721098;
Nearest TSS
ENST00000382410/Upstream/95189; ENST00000243911/Downstream/405068;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/1123950, chr20-CpG: 165/Downstream/403143
Nearby gene
DOK5(-907752) ; CBLN4(+396951) ;
Upstream sequence
ttgccaactatccaatcagtcattcctacttaatgaagtttccatacccaacccctcaacctgaaacacacacacacacacacacacacacacaaacaaa
Downstream sequence
acaaaaaaacacacagggtttggggagttcatggatagtggaacacacagaggttccctgagtgcagtgcactcagagagggcatggaagctccaagccc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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