Basic Information
VIS ID
TVIS10008530
Fusion event
HBV-LOC107986635 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1827
Orient
-
Integrated sequence
AAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTT| |CACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAAT
Host Sequence
Chromosome
chr6
Cytoband
q21
Reference genome
GRCh37/hg19
Start
113253449/112932247 (Hg38)
End
113253449/112932247 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA6F
Target gene
LOC107986635
Nearest miRNA
hsa-mir-10398/Upstream/6148027; hsa-mir-1202/Downstream/6136800;
Nearest TSS
ENST00000381078/Upstream/450611; ENST00000415883/Downstream/435697;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/564719, chr6-CpG: 205/Downstream/926311
Nearby gene
RFPL4B(-580951) ; MARCKS(+925078) ;
Upstream sequence
ACAATTATTTCAGTTTAGTTTGAGTTTATAGAGAACACAAATTTTTCCATGGATTAGATGAATATACCCAAGTCATGTAAAAATAAACTAAAATGGACTA
Downstream sequence
CATCAAGCAAACTTCACAAAGCCATGACCTATTTTGATAAAATTCAGGCAAGTTTTCAAGTGGATTTTTTCTATACCAACCAACGAGTTTGTTGTTTGAA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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