Basic Information
VIS ID
TVIS10008534
Fusion event
HBV-chrX integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2265
Orient
-
Integrated sequence
TGTCAACACTAATATGGGCCTAAAGTTCAGGCAACTCTTGTGGTTTCACATTTCTTGTCTCACTTTTGGAAGAGAAACAGTTATAGAGTATTTGGTGTCT| |TTCGGAGTGTGGATTCGCACTCCTCCAGCTTATAGACCACCAAATGCCCCTATCCTATCAACACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGT
Host Sequence
Chromosome
chrX
Cytoband
p22.2
Reference genome
GRCh37/hg19
Start
16792804/16774681 (Hg38)
End
16792804/16774681 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-3690-1/Upstream/147596; hsa-let-7f-2/Downstream/651200;
Nearest TSS
ENST00000429181/Upstream/54910; ENST00000398155/Downstream/11746;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/54705, chrX-CpG: 124/Downstream/11075
Nearby gene
SYAP1(-11997) ; TXLNG(+11751) ;
Upstream sequence
gagacagatgccttcctcttgtctcaactgcaagaggcattccttcctcttttactaatcctcctcagcacagaccctttacgggtgtcaggctggggga
Downstream sequence
tcttgagcaaagaattagacaaaacgcacaaagcaaggaaggaatgaagggatttattgaaaatgaaagtacactccacagggtttgagcaggcccaagc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate