Basic Information
VIS ID
TVIS10008544
Fusion event
HBV-PROSER2-AS1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|Polymerase|
Start
1611
Orient
-
Integrated sequence
CGACCGACCACGGGGCGCACCTCTCTTTACGCGGACTCCCCGTCTGTGCCTTCTCATCTGCCGGACCGTGTGCACTTCGCTTCACCTCTGCACGTCGCAT| |GGAGACCACCGTGAACGCCCACCAAATATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTC
Host Sequence
Chromosome
chr10
Cytoband
p14
Reference genome
GRCh37/hg19
Start
11935445/11893446 (Hg38)
End
11935445/11893446 (Hg38)
Orient
+
Location type
ncRNA_intronic
Target gene
PROSER2-AS1
Nearest miRNA
hsa-mir-3155a/Upstream/5741169; hsa-mir-107/Downstream/237314;
Nearest TSS
ENST00000439456/Upstream/18651; ENST00000437298/Downstream/1254;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/23013, chr10-CpG: 63/Downstream/806
Upstream sequence
acctcctgagtagctgggattacaggcgcccatcaccacacctggctagcttttgtagttttagtagacaagggttttcatcatgttgcacaggctggtc
Downstream sequence
tggaactcctgacctcagatgattcgcccgcctcggcctcccaaactgctggaattacaggcctgagccgctgccgcccCAGCCCAGAATCTACTATTCC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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