Basic Information
VIS ID
TVIS10008546
Fusion event
HBV-chr12 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1765
Orient
-
Integrated sequence
TCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAG| |GTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGT
Host Sequence
Chromosome
chr12
Cytoband
q24.31
Reference genome
GRCh37/hg19
Start
123850392/123365845 (Hg38)
End
123850392/123365845 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA12E
Nearest miRNA
hsa-let-7i/Upstream/1002; hsa-mir-3612/Downstream/170564;
Nearest TSS
ENST00000382841/Upstream/892; ENST00000537270/Downstream/17928;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/473, chr12-CpG: 89/Downstream/17875
Nearby gene
SBNO1(-15404) ; KMT5A(+18312) ;
Upstream sequence
TTATTAAGCGACCTAACACAATAAACATATTACCTTGTTGGTAACCCTTTTGTAAAGTCATTCTGAAAGTGCTGTTTGACTCCGTTGCTTGGGTAATAAG
Downstream sequence
CACGCCTGGGTGATTCTTGCCCCCTACTGGCTGCGCATCCTACAAGCCTAGTGCTGAAAGCAAACCAAGTAGCTGGAACAGTTGGAGGTTACAGTGTGAA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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